Turnover of employees is a big challenge for nearly every organization. Whereas, HR related policies and practices have huge impact on turnover intentions (TI) of employees in many contexts as such policies impact the attachment of the employees with the organization by enhancing their organizational commitment levels and thus leading to a considerable attention towards high commitment work-system (HCWS). The main aim of this study is to explore the relationship between HCWS and TI of employees, with the role of workload as a mediator between HCWS and TI of employees. This study is a descriptive, correlational, cross-sectional and quantitative where survey approach was used by focusing on employees, selected through convenience sampling approach, in banking sector (both public and private sector banks in Bahawalpur, Pakistan. Correlation, OLS regression analysis, Cronbach’s alpha, and KMO and Bartlett’s tests were used for data analysis purposes. Results show the significant positive relationship between the HCWS and TI of employees, while the role of workload as a mediator variable between the HCWS and TI of employees was also confirmed. This study is important one as it extends the understanding through contributing to the literature related to employees’ TI and HCWS in the context of banking sector of Pakistan. Future study should focus on other study setting with longitudinal approach.