Analysis of DAT1 (SLC6A3) RS27072 gene polymorphism, parenting style, and internet addiction tendency in adolescents: A cross-sectional study

https://doi.org/10.55214/25768484.v9i7.8731

Authors

  • Andi Ummulkhair Pawallangi Irawan Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.
  • Rinvil Renaldi Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.
  • Erlyn Limoa Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.
  • Irfan Idris Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.
  • Isra Wahid Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.
  • Sonny Teddy Lisal Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.
  • Saidah Syamsuddin Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi Indonesia.

To determine the relationship between DAT1 (SLC6A3) rs27072 gene polymorphism and parenting style in adolescents with a tendency toward internet addiction. Cross-sectional study of 443 adolescents aged 10-19 years. The study identified adolescents with a tendency toward internet addiction using the Internet Addiction Diagnostic Questionnaire (KDAI), with 84 meeting the inclusion criteria and 311 without a tendency. Parenting style was assessed using the Child Parenting Questionnaire (KPAA). The DAT1 (SLC6A3) rs27072 gene polymorphism was examined in 84 adolescents with a tendency toward internet addiction and 39 without, using PCR-RFLP and restriction enzyme methods. Statistical analysis employed Fisher's exact test and chi-square test to evaluate relationships between variables, with a significance level of p < 0.05, and binary logistic regression to predict the probability of an event based on predictor variables. The results indicated that the DAT1 (SLC6A3) rs27072 gene polymorphism is significantly associated with internet addiction tendencies in adolescents, with most exhibiting GG bands, while adolescents without such tendencies mostly display TT and TG bands. Parenting styles are also significantly associated, with adolescents exhibiting internet addiction tending to have permissive parenting, whereas non-addicted adolescents mostly have democratic parenting styles. The combination of DAT1 (SLC6A3) rs27072 gene polymorphism and parenting style is significantly associated with internet addiction tendencies. Specifically, the G allele of the DAT1 gene and an exposure (permissive) parenting style are linked to a higher likelihood of internet addiction in adolescents.

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How to Cite

Irawan, A. U. P. ., Renaldi, R. ., Limoa, E. ., Idris, I. ., Wahid, I. ., Lisal, S. T. ., & Syamsuddin, S. . (2025). Analysis of DAT1 (SLC6A3) RS27072 gene polymorphism, parenting style, and internet addiction tendency in adolescents: A cross-sectional study. Edelweiss Applied Science and Technology, 9(7), 823–834. https://doi.org/10.55214/25768484.v9i7.8731

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Published

2025-07-09